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Pharmacology 3

Number of questions: 34

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1) Histamine
  1. is classified as a mast cell release inhibitor
  2. is one of the substances released during an allergic response
  3. is found in white blood cells known as neutrophils
  4. does not cause skin reactions
Answers are locked. Please click here to buy them. 2) Mast cells:
  1. are only found in the bloodstream
  2. are coated with immunoglobulins that recognize antigens
  3. have no other role than antiallergy in the body
  4. degranulate when the H 1 -receptor is stimulated
Answers are locked. Please click here to buy them. 3) An acute allergic response
  1. can be blocked only by histamine
  2. cannot be prophylactically treated
  3. is characterized by itching, sneezing, and edema
  4. is only characterized by wheals and urticaria
Answers are locked. Please click here to buy them. 4) Antihistamines like chlorpheniramine
  1. are the newest, third-generation drugs
  2. are effective and can cause drowsiness
  3. are not found in OTC products
  4. do not have anticholinergic properties
Answers are locked. Please click here to buy them. 5) Fexofenadine and cetirizine
  1. are more selective for peripheral H 1-receptors
  2. bind the H 1 -receptors in the brain to produce fewer side effects
  3. are more sedating and drying than diphenhydramine
  4. are mast cell stabilizers
Answers are locked. Please click here to buy them. 6) Mast cell stabilizers work by blocking
  1. histamine after it is released
  2. H 1 -receptors from binding histamine
  3. the release of histamine and other active substances from mast cells
  4. the effect of histamine after it binds
Answers are locked. Please click here to buy them. 7) Select the first-generation antihistaminic drug.
  1. promethazine
  2. cetirizine
  3. loratadine
  4. levocetirizine
Answers are locked. Please click here to buy them. 8) The bronchodilator drug that would provide the longest duration of action is
  1. epinephrine (Adrenaline)
  2. ipratropium (Atrovent)
  3. salmeterol (Serevent)
  4. theophylline (Elixophylline)
Answers are locked. Please click here to buy them. 9) The drug used in the treatment of asthma that blocks the leukotriene receptor is
  1. fluticasone
  2. cromolyn
  3. albuterol
  4. montelukast
Answers are locked. Please click here to buy them. 10) The only drug class that provides immediate relief of an acute asthmatic attack is
  1. anticholinergics
  2. beta adrenergics
  3. methylxanthines
  4. corticosteroids
Answers are locked. Please click here to buy them. 11) The mechanism of action of cromolyn sodium is to
  1. produce bronchodilation
  2. increase expectoration of mucus
  3. inhibit release of mast cell mediators
  4. liquefy bronchial secretions
Answers are locked. Please click here to buy them. 12) The drug used in asthma to block IgE antibodies is
  1. cromolyn
  2. omalizumab
  3. ipratropium
  4. guaifenesin
Answers are locked. Please click here to buy them. 13) The chemical mediators involved in asthma include
  1. ECF-A
  2. leukotrienes
  3. only prostaglandins and leukotrienes
  4. all of these
Answers are locked. Please click here to buy them. 14) Parasympathetic activation of the respiratory tract causes which of the following?
  1. bronchodilation
  2. increased cyclic AMP
  3. increased mucus secretion
  4. stimulation of the beta-2 receptors
Answers are locked. Please click here to buy them. 15) Select the mechanisms of action for terbutaline (a beta-2 agonist).
  1. inhibit release of mediators from mast cells
  2. block beta-2 receptors
  3. activate beta-receptor and relax smooth muscle
  4. only inhibit release of mediators from mast cells and relax smooth muscle
Answers are locked. Please click here to buy them. 16) Corticosteroids are used in the treatment of asthma in which of the following ways?
  1. decrease activation of arachidonic acid
  2. decrease the expression of pro-inflammatory mediators and production of pro-allergic antibodies
  3. increase the production of pro-allergic antibodies
  4. only decrease activation of arachidonic acid and decrease the production of allergic antibodies
Answers are locked. Please click here to buy them. 17) The bactericidal antibiotic that interferes with bacterial cell-wall synthesis and that may cause "red man syndrome" if injected too rapidly is
  1. piperacillin
  2. vancomycin
  3. gentamicin
  4. clindamycin
Answers are locked. Please click here to buy them. 18) The antibiotic whose adverse effects include heartburn, photosensitivity, and possible depression of bone growth in young children is
  1. erythromycin
  2. tetracycline
  3. gentamicin
  4. clindamycin
Answers are locked. Please click here to buy them. 19) The main pharmacokinetic feature of aminoglycosides is that they are
  1. lipid soluble
  2. well absorbed orally
  3. poorly absorbed from the GI tract and excreted mostly unchanged in the urine if injected
  4. devoid of serious adverse effects
Answers are locked. Please click here to buy them. 20) Griseofulvin is useful in dermatophytic infections because it
  1. binds to keratin
  2. is fungicidal
  3. forms ergosterol in hair and nails
  4. incorporates itself into fungal RNA
Answers are locked. Please click here to buy them. 21) Which of the following is NOT correct about antifungal drugs or fungal infection?
  1. systemic infection may occur in patients who are receiving drugs to suppress their immune system
  2. warts are an example of a dermatophytic fungal infection
  3. the majority of antifungal drugs interfere with fungal cell-wall integrity
  4. amphotericin B is associated with serious renal toxicity
Answers are locked. Please click here to buy them. 22) Which antifungal drug is matched with its correct mechanism of action?
  1. echinocandins inhibit polysaccharide (glucan) synthesis in the cell wall
  2. flucytosine binds to the cell membrane
  3. ticonazole is an antimetabolite for fungal RNA
  4. amphotericin B binds to a cytochrome P450-dependent enzyme
Answers are locked. Please click here to buy them. 23) Which drug is effective against systemic viral infections?
  1. butenafine
  2. gentian violet
  3. clotrimazole
  4. enfuvirtide
Answers are locked. Please click here to buy them. 24) The mechanisms of action for antiviral medications include
  1. changing cell-wall synthesis
  2. binding to ergosterol
  3. inhibiting cell mitosis
  4. inhibiting neuraminidase
Answers are locked. Please click here to buy them. 25) Which of the following is NOT true of the treatment for viral infections?
  1. immunity can be gained through the attenuated live virus
  2. treatment can be given via an intranasal spray
  3. the vaccines are contraindicated in people allergic to eggs
  4. effective treatment occurs only with respiratory drug administration
Answers are locked. Please click here to buy them. 26) The antimetabolite that blocks DNA synthesis by interfering with folic acid is
  1. mercaptopurine
  2. fluorouracil
  3. methotrexate
  4. cytarabine
Answers are locked. Please click here to buy them. 27) The drug that binds to mitotic tubules to cause metaphase arrest is
  1. doxorubicin
  2. asparaginase
  3. etoposide
  4. vincristine
Answers are locked. Please click here to buy them. 28) Enzyme inhibition of aromatase is the mechanism of action of
  1. tamoxifen
  2. anastrozole
  3. leuprolide
  4. goserelin
Answers are locked. Please click here to buy them. 29) The monoclonal antibody that inhibits vascular endothelial growth factor (VEGF) and new blood vessel formation is
  1. imatinib
  2. trastuzumab
  3. bevacizumab
  4. gefitinib
Answers are locked. Please click here to buy them. 30) Which of the following is true of chemotherapy?
  1. one of the early goals of chemotherapy is remission
  2. antineoplastic drugs only attack cancerous cells
  3. drug resistance is increased with combination therapy
  4. it is the primary form of treatment for solid tumors
Answers are locked. Please click here to buy them. 31) Select the correct statements for alkylating drugs.
  1. decrease cells' ability to synthesize proteins
  2. are cell-cycle nonspecific
  3. bind irreversibly with nucleic acids and are cell-cycle nonspecific
  4. all statements are true
Answers are locked. Please click here to buy them. 32) The mechanisms of actions for the antimetabolites include
  1. blocking DNA synthesis
  2. forming abnormal nucleotides
  3. preventing DNA replication and forming abnormal nucleotides
  4. all of these
Answers are locked. Please click here to buy them. 33) Select the correct statements about the plant extract treatments for cancer.
  1. they can bind to microtubules
  2. they induce enzymes
  3. they increase DNA strand breakage
  4. they can bind to microtubules, and they increase DNA strand breakage
Answers are locked. Please click here to buy them. 34) Which of the following is correct about viruses?
  1. active infection is the only way to develop immunity to the microorganism
  2. viruses attach to the keratin protein and remain dormant for years
  3. viruses can quickly develop resistance to drugs
  4. viruses die as soon as they land on hard surfaces
Answers are locked. Please click here to buy them.

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